Archive for 2012-08-12

Depression and stress can shrink your brain

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WASHINGTON: Severe depression or chronic stress can cause your brain to shrink and lead to emotional and cognitive impairment, a new study has claimed. A team of researchers led by Yale scientists discovered that one reason for this condition is a single genetic switch that triggers loss of brain connections in humans and depression in animal models.
The findings, published in the journal 'Nature Medicine' , show that the genetic switch known as a transcription factor represses the expression of several genes that are necessary for the formation of synaptic connections between brain cells, which in turn could contribute to loss of brain mass in the prefrontal cortex of the brain.
"We wanted to test the idea that stress causes a loss of brain synapses in humans ," said senior author Ronald Duman, the Elizabeth Mears and House Jameson professor of psychiatry and professor of neurobiology and of pharmacology.
"We show that circuits normally involved in emotion , as well as cognition, are disrupted when this single transcription factor is activated ," Duman said.
Scientists analysed tissue of depressed and non-depressed patients donated from a brain bank and looked for different patterns of gene activation. The brains of patients who were in depression exhibited lower levels of expression in genes that are required for function and structure of brain synapses.
Lead author and postdoctoral researcher H J Kang discovered that at least five of these genes could be regulated by a single transcription factor called GATA1
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